Analysis of quality, aggregation and toxicity of amyloid beta peptide produced by JPT

Wild type A1-37, A1-38, A1-40, A1-42, A1-43. These peptides represent the range of naturally present A peptide lengths in the brains of healthy and diseased subjects as a result of variable -secretase induced cleavage of the Amyloid Precursor Protein (APP). Patients suffering from Alzheimer’s disease often produce the longer forms of A (A1-42, A1-43) while healthy subjects produce more of the shorter A1-37, A1-38 and A1-40. (Younkin 1998, Wiltfang et al 2002, Lewczuk et al 2003, Maddalena et al 2004).